While very low-depend MBL not often progresses to CLL, large-rely MBL progresses to CLL demanding therapy at a charge of one% to two% per annum. Significant-depend MBL is distinguished from Rai 0 CLL determined by whether or not the B-cell count is higher than or under 5 × 109/L. Whilst men and women with both of those large-rely MBL and CLL Rai p